Publication list

Lambros M, Moreno J, Fei Q, Parsa C, Orlando R & Van Haute L. (2023) Transcriptome sequencing reveals the mechanism behind the chemically induced oral mucositis in a 3D cell culture model. IJMS 24(5):5058

Van Haute L, et al. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nat Commun

Van Haute L, et al. (2021) Detection of 5-formylcytosine in mitochondrial transcriptome. Methods Mol Biol 2192:59-68

Van Haute L, et al. (2019) METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res 47(19):10267-10281

Van Haute L, et al. (2019) NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res 47(16):8720-8733

Van Haute L, et al. (2017) Dealing with an unconventional genetic code in mitochondria: the biogenesis and pathogenic defects of the 5-formylcytosine modification in mitochondrial tRNAMet. Biomolecules 7(1):24

Van Haute L, et al. (2016) Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3. Nat Commun 7:12039

Van Haute L, et al. (2015) Mitochondrial transcript maturation and its disorders. J Inherit Metab Dis 38:655-80

Van Haute L, et al. (2013) Human embryonic stem cells commonly display large mitochondrial DNA deletions. Nat Biotechnol 31:20-3

Van Haute L, et al. (2011) Generation of Lung Epithelial-Like Tissue from hESC by Air–Liquid Interface Culture. Springer Protocol Handbooks. Human Embryonic and Induced Pluripotent Stem Cells. 405-411.

Van Haute L, et al. (2009) Generation of lung epithelial-like tissue from human embryonic stem cells. Respir Res 10:105

Other publications

Silva-Pinheiro P, et al. (2022) A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome. Nat Biomed Eng

Rebelo-Guiomar P, et al. (2022) A late-stage assembly checkpoint of the human mitochondrial ribosomal large subunit. Nat commun 13(1):929

Silva-Pinheiro P, et al. (2022) In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue. Nat commun 18(1):750

Ohkubo A, et al. (2021) The FASTK family proteins fine-tune mitochondrial RNA processing. PloS Genet 17(11):e1009873

D’Souze AR, et al. (2021) YbeY is required for ribosomal small subunit assembly and tRNA processing in human mitochondria. Nucleic Acids Res 49(10):5798-5812

Palenikova P, et al. (2021) Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes. Biochim Biophys Acta Bioenrg 1862(6):148399

Park, et al. (2019) The structure of human EXD2 reveals a chimeric 3’ t 5’ exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Res 47(13):7078-7093

Rebelo-Guimar P, et al. (2019) The mammalian mitochondrial epitranscriptome. Biochim Biophys Acta Gene Regul Mech 1862(3):429-446

Hoitzing H, et al. (2019) Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations. PLoS Comput Biol 1(6):e1007023

Gammage PA, et al. (2018) Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nat Med 24(11):1691-1695

Pearce SF, et al. (2017) Maturation of selected human mitochondrial tRNAs requires deadenylation. Elife 6:e27596

Gammage PA, et al. (2016) Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Res 44(16):7804-16

Geens M, et al. (2016) Female human pluripotent stem cells rapidly lose X chromosome inactivation marks and progress to a skewed methylation pattern during culture. Mol Hum Reprod 4:285-98

Karniely S, et al. (2016) Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries. MBio 7:2

Gammage PA, et al. (2016) Engineered mtZFN's for Manipulation of Human Mitochondrial DNA Heteroplasmy. Methods Mol Biol 1351:145-62

Spits C, et al. (2006) Whole-genome multiple displacement amplification from single cells. Nat Protoc. 1:1965-70.

Spits C, et al. (2006) Optimization and evaluation of single-cell whole-genome multiple displacement amplification. Hum Mutat. 27:496-503.

De Vriese AS, et al. (2006) Linezolid-induced inhibition of mitochondrial protein synthesis.  Clin Infect Dis. 15:1111-7