Transcriptomics analysis

Transcriptomics, a branch of genomics focusing on the study of RNA molecules, particularly messenger RNA (mRNA), has become a pivotal tool in unraveling the intricate language of genes. NGS allows researchers to explore the entire transcriptome, providing a comprehensive snapshot of the RNA molecules present in a biological sample. This wealth of information extends beyond traditional gene expression studies, encompassing alternative splicing, non-coding RNA identification, and the detection of rare or low-abundance transcripts.

In cancer research, transcriptomics plays a crucial role in elucidating the molecular mechanisms underlying tumorigenesis. RNA-Seq, a powerful transcriptomic analysis technique, enables researchers to not only quantify gene expression levels but also identify novel transcripts and isoforms that may be dysregulated in cancer cells. This information is instrumental in understanding the functional consequences of genetic alterations, pinpointing potential therapeutic targets, and predicting patient outcomes. Beyond oncology, transcriptomics finds applications in diverse fields, including developmental biology, neuroscience, and infectious diseases, offering a nuanced understanding of biological processes at the molecular level.

Selection of our publications

Lambros M, Moreno J, Fei Q, Parsa C, Orlando R & Van Haute L. (2023) Transcriptome sequencing reveals the mechanism behind the chemically induced oral mucositis in a 3D cell culture model. IJMS 24(5):5058 doi: 10.3390/ijms24055058

Van Haute L, et al. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nat Commun doi: 10.1038/s41467-023-36277-7